One of the biggest problems you have when designing a new page layout is thinking up ways to layout your content.
Just scroll through the wire frames pages and find a block that you think will be a suitable container for the content you have.
For instance, photos above text might suit the content you have. Or icons, headlines and paragraph text might be a better fit for your content and your circumstances.
I made full width and fixed width pages with the same layouts and content on both pages, so whichever type of theme you have you should be able to get an idea of what your own site layout would look like.
I hope you find them useful.